With the in-depth study of the mechanism of pyroptosis triggered by SARS-CoV-2, it was found that NSP6 in non-structural proteins (74, 168), N-protein (169), and S-protein (170) in structural proteins, and ORF3a protein (171) in auxiliary proteins all lead to overexpression and activation of NLRP3 inflammasome and caspase-1 and are positively correlated with the severity of COVID-19 (164). This evidence concerns the gene PROS1 and COVID-19.