Bioinformatic analysis revealed that COVID-19, RA, and pyroptosis-related genes were enriched in pyroptosis and pro-inflammatory pathways (NLR/TLR signaling pathway, NLRP3 inflammasome complex, death-inducing signaling complex, regulation of interleukin production), natural immune pathways (activation of the NLRP3 inflammasome by SARS-CoV-2) and COVID-19-and RA-related cytokine storm pathways (IL, NF-κB, TNF signaling pathway and regulation of cytokine-mediated signaling). This evidence concerns the gene NLRP3 and rheumatoid arthritis.