35 Co-genes were obtained by the intersection of COVID-19, RA (GSE55235), and pyroptosis-related genes enriched in NLR/TLR signaling pathway, NLRP3 inflammasome complex, death-inducing signaling complex, regulation of interleukin production and cytokine production involved in immune responses. The gene discussed is NLRP3; the disease is rheumatoid arthritis.