In this study, the top 11 hub genes pathways of COVID-19, RA, and pyroptosis were enriched in the Network map of the SARS-CoV-2 signaling pathway, Activation of the NLRP3 inflammasome by SARS-CoV-2, IL, NF-κB, TNF signaling pathway and regulation of cytokine-mediated signaling pathway. Here, NLRP3 is linked to COVID-19.