It was demonstrated that monocytes in COVID-19 patients are the outposts of SARS-CoV-2 invasion via TLR sensing and can release inflammatory cytokines by assembling NLRP3, activating caspase-1 to generate a “cytokine storm,” and synthesizing GSDMD-NT to induce cellular pyroptosis (72, 168). The gene discussed is NLRP3; the disease is COVID-19.