SARS-CoV-2 proteins, ORF3a, M, ORF7a, and N, activates the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) and produce pro-inflammatory cytokines (IL-1, IL-6, IL-8, TNF-α) that further activates NF-κB by a positive feedback mechanism, resulting in uncontrolled inflammation in the COVID-19 patients (38). The gene discussed is IL6; the disease is COVID-19.