PDCD1 and neoplasm: Ninety-seven (37.6%) patients had ECOG PS of 1, 157 (60.9%) had intrahepatic tumors > 3, 157 (60.9%) had maximum tumor diameter > 5 cm, and 76 (29.5%) had Child-Pugh class B. Overall, 195 (75.6%) patients were in BCLC stage C and had indications for PD-1 inhibitors and anti-angiogenic agents.