miR-4512 regulates the level and type of chemokines by TLR4 and C-X-C motif chemokine ligand (CXCL)2 pathway, which point out that the miR-4512-TLR4-CXCL2 axis as a potential novel therapeutic target in SLE (68). Here, TLR4 is linked to systemic lupus erythematosus.