Hsa-miR-127-3p, a microRNA whose expression is downregulated in renal tissues of LN patients, is associated with upregulation of Janus kinase 1 (Jak1) and IFN stimulated genes (ISGS) in renal tissues of LN patients, leading to hyperactivation of the IFN-I signaling pathway in the kidneys of LN patients (63). The gene discussed is JAK1; the disease is lobular neoplasia.