Based on the current study, the relevant literature directly or indirectly confirms that the expression of C1QA/B (29–33), MX1 (25, 27), RORC (34), CD177 (35, 36), DEFA4 (37, 38), and HERC5 (39, 40) is strongly correlated with SLE/LN activity in a broad sense. This evidence concerns the gene HERC5 and systemic lupus erythematosus.