According to the marker genes in the study of Neftel et al, neoplastic cells were split across four pan-glioma cell states, AC-like (EGFR), MES-like (CHI3L1), NPC-like (ELAVL4) and OPC-like (PDGFRA) (9), that observed across many glioma single-cell studies (36, 37). This evidence concerns the gene EGFR and central nervous system cancer.