Genetic polymorphisms in genes such as CARD9 increase the risk of IFD (92)34 genes, were mainly associated with type I/type II IFN and TNF-α signaling, and neutrophil degranulation were downregulated in CAPA pts (23). IL8 and Caspase 3 significantly lower in CAPA pts (58). This evidence concerns the gene SGCG and episodic ataxia type 2.