KCNE1 and Ventricular arrhythmia: In Xenopus oocytes, the co-expression of SGK3 and KCNE1/KCNQ1 could up-regulate the KCNE1/KCNQ1-induced current, and the mutation of KCNE1/KCNQ1 led to Jervell and Lange–Nielsen syndrome, which is a disorder characterized by congenital profound sensorineural deafness, cardiac long QT syndrome, ventricular arrhythmias, and sudden cardiac death (Embark et al., 2003; Faridi et al., 2019).