In short, SGK3 can tune GluR1, GluR6, EAAT1, EAAT2, EAAT4, EAAT5, and SN1 (Figure 4), participating in the transport of glutamate and glutamine in the nervous system, and play a role in the (patho) physiological process of various nervous system diseases (Table 4). This evidence concerns the gene GRIK2 and nervous system disorder.