The loss-of-function mutation of potassium voltage-gated channel subfamily J member 2 (KCNJ2), the encoding gene of Kir2.1, could lead to Andersen–Tawil syndrome accompanied by periodic paralysis, cardiac arrhythmia, and dysmorphic features (Seebohm et al., 2012). This evidence concerns the gene KCNJ2 and cardiac rhythm disease.