Some genes involved in the axes were proved functional in IDD, including ZFP36/miR-155-5p/FOS, BTG2/hsa-miR-185-5p/SOCS3, and COL9A2/hsa-miR-664a-5p/IBA57 (Osuka et al., 2014; Meng et al., 2016; Makino et al., 2017; Xu et al., 2022) by regulating ECM metabolism and immune response; however, the function of more axes still remains unclear. The gene discussed is IBA57; the disease is intervertebral disk degenerative disorder.