TNF and Melnick-Needles syndrome: As highlighted in Table 4, the concentrations of TNF-α and IL-6 in the peri-infarct zone of LV tissues were significantly higher in the MNS group 1 (TNF-α: 0.21 ± 0.06 ng/mg vs. 0.13 ± 0.02 ng/mg, P = 0.02; IL-6: 0.16 ± 0.07 ng/mg vs. 0.08 ± 0.02 ng/mg, P = 0.03) and the MNS group 2 dogs (TNF-α: 0.30 ± 0.08 ng/mg vs. 0.13 ± 0.02 ng/mg, P < 0.01; IL-6: 0.26 ± 0.08 ng/mg vs. 0.08 ± 0.02 ng/mg, P < 0.01) than in the control group dogs.