PTH and Cushing syndrome due to macronodular adrenal hyperplasia: However, when the threshold was gene count >2 and p < 0.05, the pathway was majorly enriched in cytokine–cytokine receptor interactions; osteoclast differentiation; human T-cell leukemia virus 1 infection; Cushing syndrome; the relaxin signaling pathway; parathyroid hormone synthesis, secretion, and action; insulin secretion; and leishmaniasis (Figure 3C).