VWF and stroke disorder: Many clinical stroke risk factors (e.g., obstructive sleep apnea, left atrium dilatation, and renal impairment) (6–8) as well as some biomarkers (e.g., troponin, natriuretic peptides, and von Willebrand factor) (9, 10) are closely related to the stroke risk, but they do not improve the predictive value of CHA2DS2-VASc score.