A recent study provided a mechanistic explication for these observations, as it was that retinoic treatment reprograms the enhancer landscape and alters the noradrenergic core regulatory circuitry (NOR-CRC) of NB cells, by reducing the expression of the transcription factors Phox2b, GATA3, and MYCN (50). Here, PHOX2B is linked to colorectal carcinoma.