A limitation of this study is that our cohort of NB and PHEO/PGL samples used for the measurement of CATs and MNs in plasma and tumor tissue, as well as NV detection, is only partially complete (some samples were not available for metabolite, mRNA, or protein quantification because of material scarcity), as detailed in Supplementary Tables 1A, B. Here, PIMREG is linked to neoplasm.