KISS1 and hypogonadotropic hypogonadism: Interestingly, SNPs of KISS1 associated with hypogonadotropic hypogonadism indicate that SNPs which decrease the hydrophilicity of kisspeptins may lead to delayed puberty; such SNPs have been identified and characterized by in-silico analysis, further in-vitro work is needed to corroborate in-silico models (22).