When it comes to non-NIS-avid lesions, they may be detected by 18F-FDG PET/CT at the level of tumor metabolism and reflected by 68Ga-prostate-specific membrane antigen (68Ga-PSMA) PET/CT as well as 99mTc/68 Ga-arginine-glycine-aspartic acid (68Ga-RGD) PET/CT at the level of neovascular development 68.Ga-DOTATATE and 68Ga-fibroblast-activation-protein inhibitors (68Ga-FAPI) PET/CT can demonstrate the expression of somatostatin receptors (SSTRs) and extracellular fibrosis of tumors, respectively (51–55). This evidence concerns the gene FOLH1 and neoplasm.