A systematic review and meta-analysis of nine observational studies including offspring of PCOS women from Chile, Netherlands and the US re-analyzed the data with/without stratifying for the sex of the offspring and summarized cardiometabolic health as metabolic sum scores 1 (BMI + systolic BP (SBP) + insulin levels + TG + high-density lipoprotein cholesterol (HDL-c)) and 2 (waist-to-height ratio + SBP + glucose + TG + HDL-c). Here, INS is linked to polycystic ovary syndrome.