In the milepost United Kingdom Prospective Diabetes Study (UKPDS), intensive glucose control with insulin or sulphonylureas reduced the relative risk of microalbuminuria or proteinuria by 33% and the proportion of patients doubled their plasma creatinine levels at 12 years (0.91% vs. 3.52%, respectively; P = 0.0028) (96, 97). The gene discussed is INS; the disease is diabetes mellitus.