A previous study investigated the association between UA concentrations and the standard deviation scores (SDS) of insulin-like growth factor 1 (IGF-1) in children and adolescents with idiopathic short stature (ISS); IGF-1 SDS was positively associated with appropriate serum UA concentrations, whereas serum UA levels that were too high or too low were associated with lower IGF-1 SDS values (4). This evidence concerns the gene IGF1 and short stature due to GHSR deficiency.