In all of these studies, REE was measured using indirect calorimetry.107,110,111 When REE is calculated using prediction equations instead of being measured, it is not associated with any score or biomarker of disease activity.112 On the other hand, RA-specific equations for the calculation of REE have been proposed, taking into account the levels of CRP.113. This evidence concerns the gene CRP and rheumatoid arthritis.