Higher ESR, CRP, fibrinogen, white blood cell count, and serum amyloid A (SAA) are expected results in active FMF disease compared to the attack-free period.8,9 However, in a systematic review investigating APR used for FMF diagnosis, Erer et al. reported that there was no effective APR to diagnose FMF disease.9 This evidence concerns the gene ESR1 and familial Mediterranean fever.