CLOCK and metabolic disease: DRF reverses the liver clock within seven days in mice without altering the central clock located in the suprachiasmatic nucleus (SCN).4,5 DRF contributes to increased adiposity and glucose intolerance when combined with high-fat diet feeding.6–9 Conversely, night time-restricted feeding (NRF), is known to protect against metabolic diseases, such as obesity, insulin resistance, and fatty liver in rodents.10,11 Nevertheless, both DRF and NRF increase longevity in mice, when compared to arrhythmic feeding.12