TYK2 and head and neck squamous cell carcinoma: Subsequent univariate Cox regression analysis revealed that N stage and TYK2 expression were significantly associated with the overall survival, and multivariate regression analysis further indicated that TYK2 could serve as a positive independent prognostic factor in patients with HNSCC (HR = 0.641, p = 0.004) (Figures 4G, H, Supplementary Table S4).