As can be seen from the results, TYK2 expression was positively related to most immune cells, including B cell (r = 0.483, p < 0.001), NK cell (r = 0.468, p < 0.001), CD8+ T cells (r = 0.398, p < 0.001), regulatory T cells (Tregs) (r = 0.358, p < 0.001), CD4+ T cells (r = 0.343, p < 0.001), cancer associated fibroblast (r = 0.329, p < 0.001) (Figure 6A, Supplementary Table S6). Here, CD4 is linked to cancer.