The results showed that in most patients ZNF566 (8/10, 80%, Figure 13A), TMEM150C (9/10, 90%, Figure 13B), ENDOU (8/10, 80%, Figure 13C) were all significantly decrease in HNSCC tissues than in normal tissues (p < 0.005). This evidence concerns the gene TMEM150C and head and neck squamous cell carcinoma.