A recent study from Grasso et al. (2018) analyzed 1,211 primary CRC samples, including 179 MSI-H tumors, showed significantly mutated genes in immune-modulating pathways and in the antigen-presenting machinery, including biallelic losses of B2M and HLA genes and Wnt/β-catenin signaling genes were significantly mutated in all CRC subtypes, and activation of the Wnt/β-catenin signaling cascade correlated with the absence of T-cell infiltration. Here, B2M is linked to colorectal carcinoma.