MSI-H CRCs are often immune cell rich as mentioned, but the TILs may exhibit an activated and/or exhausted phenotype (higher expression of TIGIT, LAG3, TIM3, and PD1/PDL1), elevated T regulatory cells, and other immunosuppressor cells, such as tumor-associated myeloid cells, based on previous reports (Lin et al., 2020) (Xiao and Freeman, 2015). This evidence concerns the gene LAG3 and neoplasm.