Using LASSO and multivariate Cox regression, we included four genes and constructed cuproptosis gene-related signatures containing FDX1, DLD, DLAT, and CDKN2A, of which FDX1, DLAT, and CDKN2A are correlated with CCRCC prognosis (Bian et al., 2022). The gene discussed is CDKN2A; the disease is nonpapillary renal cell carcinoma.