Using LASSO and multivariate Cox regression, we included four genes and constructed cuproptosis gene-related signatures containing FDX1, DLD, DLAT, and CDKN2A, of which FDX1, DLAT, and CDKN2A are correlated with CCRCC prognosis (Bian et al., 2022). Here, DLAT is linked to nonpapillary renal cell carcinoma.