In addition, there was a negative correlation between TEXScore and pathways, such as tumor formation, including ERBB signaling pathway and WNT signaling pathway, and a positive correlation with mismatch repair, antigen processing, and presentation, indicating the effectiveness of risk assessment scores in describing the relative status of tumor activation pathways and antitumor immune depletion in glioma samples. This evidence concerns the gene EGFR and central nervous system cancer.