Activation of the PI3K/Akt/Glut-4 pathway has been known to be significantly involved in the regulation of insulin signaling and glucose metabolism and defects in the insulin signaling pathway, which lead to glucose homeostasis could lead to insulin resistance (Marinho et al., 2014; Rai et al., 2019; Kowalczuk et al., 2021; John et al., 2022). The gene discussed is INS; the disease is Insulin resistance.