Apart from an observational pilot study using a prolongation of overnight fasting that demonstrated a weight loss in consequence of reduced calorie intake but no change in insulin sensitivity (estimated by the homeostasis model assessment, HOMA + IR) (Arnason et al., 2017), studies on the effect of ADF on glucose homeostasis in patients with type 2 diabetes are sparse. The gene discussed is INS; the disease is type 2 diabetes mellitus.