Glucose rate of appearance (Ra) after an overnight fast in the baseline test was increased in T2DM compared with OB (3.7 ± 0.2 vs. 3.1 ± 0.1 mg/min/kg, respectively (p < 0.05)), and decreased (p < 0.05) in both groups with insulin infusion during the clamp (to -0.1 ± 0.2 and 0.2 ± 0.2 mg/min/kg, respectively (p > 0.05)). Here, INS is linked to type 2 diabetes mellitus.