INS and type 2 diabetes mellitus: In the part of the experiment with allowed weight loss (ADF + WL), which included a ∼4% loss of body weight, ∼13% loss of visceral fat, and 36 ± 27% (range: 0%−84%) loss of intrahepatic triglyceride content, a significant increase in insulin secretion (compared with baseline) was demonstrated in a subgroup of patients with type 2 diabetes.