WEE1 and Glucose intolerance: The selection of glucose and fatty acids by the body is a dynamic process (Randle et al., 1963), elevated fatty acid levels lead to glucose intolerance, which induces IR, increases lipolytic reactions, reduces mitochondrial fatty acid oxidation in IR populations, leaded to the accumulation of diacylglycerols and ceramides by reverse synthesis, further stimulating protein kinases and inhibiting insulin signaling (Morino et al., 2006; Savage et al., 2007), created a vicious cycle.