For proteins that enriched in the S/C group, the KEGG analysis showed a strong interaction with a series of pathways related with neurodegenerative disease, such as Hippo signaling pathway-multiple species (Gogia et al., 2019), ABC transporters (Pahnke et al., 2021), oxidative phosphorylation, and ErbB signaling pathway (Supplementary Figure 3; Sun et al., 2020). The gene discussed is ABCG2; the disease is neurodegenerative disease.