In this study, preoperative lung transplant patients show multiple comorbidities, including type 2 diabetes mellitus, hypertension, chronic kidney disease, and OSA, with the primary lung pathology interstitial pulmonary fibrosis, COPD/Emphysema, hypersensitivity pneumonitis, connective tissue disease, Alpha-1-Anti-Trypsin Disease, Bronchiolitis Obliterans, pulmonary arterial hypertension, and cystic fibrosis. This evidence concerns the gene PSMA6 and pulmonary arterial hypertension.