In this study, we retrospectively evaluated the diagnostic performance of a 7-AAB panel (p53, PGP9.5, SOX2, GAGE7, GBU4-5, MAGEA1 and CAGE) in lung cancer and compared it with CT and PET-CT for pulmonary nodules with different diameters, stages, imaging features, and pathological types in the same population. Here, TP53 is linked to lung cancer.