VEGFA and hepatocellular carcinoma: Exosomes released from cancerous hepatocyte-like CD90+ HCC cells transfected with lncRNA H19 can produce and secrete VEGF (vascular endothelial growth factor) and its receptor VEGF-R1 in HUVEC, then increase the ability of HUVEC cells to align into tubular structures in vitro, and promote heterotypic adhesion of endothelial cells to CSC-like hepatocytes (36).