EZH2 and hepatocellular carcinoma: In a feedback loop formed by miR-144/miR-451a clusters and EZH2, the catalytic subunit of the polycomb repressor complex (PRC2), miR-144 targets EZH2 and PRC2 through histone H3K27 methylation of the promoter for miRNA gene epigenetic suppression; simultaneously, TAM remodels and promotes the progression of HCC.