(78) found that miR-144/miR-451a clusters target and reduce the secretion of hepatocyte growth factor (HGF) and macrophage migration inhibitory factor (MIF) in HCC cells through paracrine signaling, resulting in the impairment of macrophage M2 phenotype and the promotion of M1 polarization, which facilitates phagocytosis and the activation of cytotoxic T lymphocytes for antitumor activity. This evidence concerns the gene MIF and hepatocellular carcinoma.