The GSEA analysis indicated that mutation of gene ATRX was related to “humoral immune response” (Supplementary Figure 3), and now it has been reported in many tumors including pleomorphic Sarcomas (52), glioma (53, 54), gastric cancer patients (55), while the relationship between mutation of ATRX with cytochrome P450 was not reported. This evidence concerns the gene ATRX and glioma.