In this study, from the results interpreted in cBioPortal, we found that mutations in ACO2 were most common in SKCM, followed by UCEC, CHOL, UCS, STAD and PAAD, which suggests that we should pay attention to the relationship between ACO2 gene mutation and digestive system and female reproductive system tumors. The gene discussed is ACO2; the disease is female reproductive system neoplasm.