PABPC1 and cancer: Changes in mRNA translation in tumors are more extensive than those in transcription downstream of aberrant signaling pathways, and in response to oncogenic signaling or microenvironmental stressors, alterations in intracellular mRNA translation allow rapid changes in the proteome, increasing cancer cell adaptation, leading to tumor formation, spread metastasis and treatment resistance (15).There is no doubt that PABPC1 plays an important role in mRNA translation and stability as an RNA binding protein.