ATXN2 and spinocerebellar ataxia type 2: In marked contrast, positive regulation through polyadenylation has been most extensively studied in the context of early development (102).Spinocerebellar ataxia type 2 (SCA2) gene product, Ataxin-2, a member of the RNA-binding protein Like-Sm (LSm) family, is a cytoplasmic protein that binds and stabilizes many mRNA sequences, which is involved in many aspects of RNA metabolism (103), and it harbors an LSm domain and LSm-associated domain (LSmAD) within the N-terminal half.