Our gene expression analysis also shows differential expression for some of the genes of the MAPK pathway, such as Mitogen-Activated Protein Kinase 3 (MAPK3), Mitogen-Activated Protein Kinase 12 (MAPK12), which were upregulated and downregulated, respectively, in the AA colon cancer cell lines. Here, MAP4K3 is linked to colonic neoplasm.