BIRC3 and in situ carcinoma: We found that 3 independent sequences of cIAP2 siRNA, which knocked down cIAP2 expression by more than 80% (Figures 3E, F), reproducibly suppressed TFK1R cell survival under GEM/CIS treatment (Figure 3G) and lowered the GEM/CIS GR50 values when compared to the control non-target siRNA (Supplementary Table 3).