(12) showed that Src, an oncogene of the non-receptor tyrosine kinase family, induces the transformation of normal mammary epithelial cells through activation of NF-κB, and IL-6 plays an important regulatory role in this process.There are also studies indicating that IL-6 is associated with TNM staging, recurrence and metastasis of breast cancer (13). This evidence concerns the gene NFKB1 and breast cancer.