ITGB2 and osteosarcoma: Different cellular signaling pathways regarding checkpoints between two mitochondria-related signature score groups of osteosarcoma cells and microenvironment cells are shown in Figures 6A, B, in which ITGB2, HAVCR2, and LGALS9 were the most active signaling pathways in osteosarcoma cells with the high mitochondria-related signature score.