Tumor-intrinsic T-cell-exclusionary pathways typically converge on a repression of type I and/or II interferons (IFNs), and thence a paucity of IFN-induced T cell chemokines such as CXC-chemokine ligand 9 (CXCL9), CXCL10, and CXCL11 in the TME (7). The gene discussed is CXCL11; the disease is neoplasm.