CYLD and colorectal carcinoma: To further validate this finding in a mouse CRC cell line, we generated Spata2- and Cyld-knockout (KO) CT26 clones and corroborated our findings in human cell lines, wherein both Spata2- and Cyld-KO CT26 lines manifested reduced Cxcl9, Cxcl10 and Cxcl11 gene expression (Figure 2B) and CXCL10 protein expression upon IFN-γ stimulation (Figure 2C).