SPATA2 and neoplasm: In addition, an upregulation of CXCR3 expression was observed on tumor-infiltrating CD8+ T cells and NK cells in Spata2-KO and Cyld-KO tumors relative to WT tumors (Figure 5E), suggesting a potentiated CXCL9/10/11-CXCR3 signaling axis in recruiting the aforementioned cell subsets into the tumor.