Hyperbaric oxygen therapy is also used for reversing hypoxia and elimination of CSCs by modulating depleted excessive ECM, such as collagen and fibronectin, and thus normalized tumor blood vessels both structurally and functionally and was effective in enhancing the efficacy of commercialized nanomedicines, Doxil and Abraxane, against TNBC and PDAC as stroma-rich solid tumors (92). Here, FN1 is linked to neoplasm.