HRR alterations involve Fanconi anemia genes (PALB2, FANCA, FANCL, FANCI, FANCC), core RAD genes (RAD50, RAD51, RAD51B, RAD51C) as well as DNA damage response genes (ATM, ATR, CHEK1, CHEK2) (10). This evidence concerns the gene RAD50 and Fanconi anemia.