ID1 and neuroblastoma: For example, one study reported that inhibition of cyclooxygenase-2 (COX-2) promotes 1-methyl-4-phenyl 1,2,3,6 tetrahydropyridine (MPTP)-induced autophagic cell death in human NB cell line SH-SY5Y (17); another study revealed that Calcium/calmodulin-dependent protein kinase II (CAMK2) potentiates autophagic degradation of inhibitor of differentiation 1/2 (Id-1/2) and then induce cell differentiation of NB cells (14).