ULK1 and neuroblastoma: For example, one study reported that activation of autophagy in human NB cell lines alleviates amyloid-β-induced apoptosis and neurotoxicity (15); another study reported that inhibition of unc-51 like autophagy kinase 1 (ULK1) significantly reduces cell growth and promotes cell apoptosis in NB cell lines (16); one study also reported that autophagy was also associated with chemoresistance of NB (13).