For the three bad ARGs, GNAI3 and EIF2S1 have not been reported to be implicated in NB previously, however, EIF2S1 has been reported to be involved with pathogenesis of neurodegenerative diseases as a target gene of transcript factor nuclear respiratory factor 1 (NRF1) (30); Downregulation of MAP2K7 (also known as MKK7) has been reported to be associated with decreased proliferation of NB cells (31). This evidence concerns the gene NRF1 and neurodegenerative disease.