FMS-like tyrosine kinase 3 (FLT3) is the most frequent single-gene mutation in acute myeloid leukemia: about 25% of adult patients with AML have FLT3 internal tandem duplication (FLT3-ITD) and 10% have FLT3 tyrosine kinase domain (FLT3-TKD) point mutations or deletions (105). This evidence concerns the gene FLT3 and acute myeloid leukemia.