More convincingly, AUCs of ROC curves of these 20 genes were all over 0.9 except for CD274 (Figure 4 and Supplementary Figures 5A–K), suggesting that these genes were specific to ATC and could distinguish it from other types of thyroid cancer as ATC-specific markers like CDH1 (AUC = 0.99) and PAX8 (AUC = 0.97) (Supplementary Figures 5L, M), and maybe even have more diagnostic value than some other existed markers of ATC, such as CTNNB1 (AUC = 0.76) and TTF1 (AUC = 0.58) (Supplementary Figures 5N, O) at the mRNA expression level. This evidence concerns the gene CTNNB1 and thyroid cancer.