TP53 and thyroid gland carcinoma: Furthermore, based on the cBioPortal database, we discerned that much more TP53 mutation existed in ATC than in other thyroid cancers consistent with several previous studies (3, 14, 16, 56), and patients with TP53 mutation had poorer overall survival, suggesting that TP53 mutation may play an important role in occurrence and development of ATC.