Gastric cancer (GC) is the most common gastrointestinal tumor in the world, and elevated expression of programmed death ligand 1 (PD-L1) has been reported in up to 65% of GC/gastroesophageal junction cancer (GEJC) and is associated with specific molecular subtypes of gastric adenocarcinoma (1). This evidence concerns the gene CD274 and gastric adenocarcinoma.