CD274 and neoplasm: For instance, PD-L1 mRNA expression in platelet and exosomes also contribute to predicting the clinical response to immunotherapy (29), the measurement of PD-L1 mRNA expression in tumor tissue by RNA-seq is analytically and clinically in predicting the immune checkpoint inhibitor response (30), and blood expressed PD-L1 mRNA level was confirmed to be associated with anti–PD-1 response (12–14).