CDKN1A and nonpapillary renal cell carcinoma: Moreover, Zhu et al. studied the therapeutic potential of LSD1 inhibitors in ccRCC treatment and discovered that inhibition of LSD1 could decrease the H3K4 demethylation at the CDKN1A gene promoter and it was associated with P21 upregulation and cell cycle arrest at G1/S in ccRCC cells [65].