□SYP↓ cognitive deficits □hypothalamic SYP↓ Bcl2↓ cleaved caspase- 3↑ AVP secretion ↓□SYP↓ TNF-α↑ cognitive impairment cAMP response element binding protein (CREB) ↓ insulin signaling disrupted. The gene discussed is CREB1; the disease is Cognitive impairment.