According to the American Society of Medical Genetics and Genomics [24], this meaningless mutation can be classified as a possible pathogenic mutation because it is a predicted zero mutation in the TUBGCP4 gene, in which loss of function is a known mechanism of microcephaly and chorioretinopathy type 3 (MCCRP3) [25]. Here, TUBGCP4 is linked to microcephaly and chorioretinopathy 3.