We found that TUBGCP4 expression was not related to age, gender, recurrence, vascular tumor thrombus, HBsAg, portal vein tumor thrombus, liver cirrhosis, tumor capsule, distant metastasis, tumor number, pathological grade, TNM stage, carcinoembryonic antigen (CEA), or alpha-fetoprotein (AFP) levels in HCC patients but correlated with carbohydrate antigen (CA-199) levels (P < 0.05). This evidence concerns the gene TUBGCP4 and cirrhosis of liver.